女孩艾米（艾米·舒默 Amy Schumer 飾），從小被父親教導婚姻不現實，一夫一妻不現實，長大后熱衷泡吧，一直與不同男人約會卻從不戀愛。一天，身為男性雜志編輯的她，前去采訪一位專為運動員治療運動損傷的醫生亞倫（比爾·哈德爾 Bill Hader 飾），不料遇見了可能終結她完美單身生活的真命天子。　　本片由女主角艾米·舒默編劇，根據她本人的真實經歷改編。

　　Can I Get a Witness? tells the story of a mother and daughter in a near-future world where huge sacrifices are made to maintain life on Earth.　　With its resources swallowed by e-waste and overpopulation, the world is experiencing an anthropogenic collapse. To manage, technological advances are shunned. Nobody has electricity and only people with exceptions are permitted cars. Most importantly, there is also a collective agreement that nobody is allowed to live beyond the age of 50.　　Oh’s Ellie lives with her teenage daughter Kiah (Keira Jang), who is starting her first day as a Documenter, an important role in this new world order. She uses her artistic gifts — beautifully conjured in animations — to draw the dying ceremonies, since printing and photography have been banned.　　Kiah is paired with Daniel (Joel Oulette), the young man who performs the contractual elements of each person’s end-of-life ceremony. He matter-of-factly provides the packages a person can choose, sets them up when the time comes, and performs the burials. But his new coworker is having a hard time handling the emotional impacts of the job.

　　攝影師工藤太郎在坐飛機的途中發現一架太空囊墜入大海，那正是4個月前離奇失蹤的無人木星探測器赫利俄斯7號。回國后的工藤接到陪同開發公司調查隊前往塞吉歐島的工作，而塞吉歐島正位于赫利俄斯7號墜落地點的附近……　　另一方面，塞吉歐島突然出現巨大的怪獸，這一切似乎和赫利俄斯7號有關……

　　《一夜大肚》中的夫妻皮特（保羅·路德 Paul Rudd 飾）與黛比（萊斯利·曼恩 Leslie Mann 飾）如今年過四十，雖然黛比已經擁有一個不錯的精品店，皮特也開了自己的唱片公司，然而生活的暗礁還是漸漸圍困了這個家庭：不僅皮特開始需要借助“偉哥”，兩人的父母也年歲漸衰，需要供養，皮特的唱片店近來也在艱難維系，兩個還在上學的女兒更是每天把家里弄得雞飛狗跳。夫妻二人深感走入了愛情墳墓的同時，連生活的激情與樂趣也將要被消磨殆盡。黛比在與朋友談心之后，終于決定要挽救自己的婚姻，而此時，她已經懷上了皮特的第三個孩子……　　本片為導演在2007年的喜劇電影《一夜大肚》的一個獨立續集。